English proficiency:
Research projects:
- Development of nanoparticles for combination therapy of malignant neoplasms;
- Development of protocols for radiolabeling of nanoparticles for radionuclide therapy;
- Synthesis of low-molecular antitumor drugs;
- Development of methods for encapsulation of low-molecular antitumor drugs
Research topics:
- Obtaining and characterizing polymer nanocarriers for combined therapy of malignant neoplasms;
- Study of radiological stability of nanoparticles for radionuclide therapy;
- Development of methods for the synthesis of low-molecular antitumor drugs;
- Development of methods for encapsulation of low-molecular antitumor drugs
Field of study:
Research interests:
The development of multifunctional nanoscale platforms for the targeted delivery of therapeutic agents using various nanotechnology approaches has received significant attention in the field of cancer therapy. In this regard, the use of organic and inorganic nanoplatforms has already demonstrated promising results in the delivery of various therapeutic agents. At the same time, the development and search for new highly effective therapeutic compounds for targeted such therapy continues. Semi- photonic systems provide targeted delivery of these compounds in nanoscale carriers to the focus of interest without harming healthy organs and tissues of the body. To ensure maximum results, nanocapsules are additionally modified and their parameters are accurately characterized (size, charge, porosity, etc.). Combined radionuclide therapy has a number of advantages and insufficient knowledge of the effectiveness of therapeutic use for the treatment of malignant tumors. Modification and optimization of the synthesis of nanocapsules with therapeutic radionuclides, combined use with other therapies, has great potential to solve many health problems.
Research highlights:
- 1. Patent for invention No 2 806 147
- Patent for invention No 2 806 148
- Patent for invention No 2 818 267
- Patent for invention No 2 806 324
- Patent for invention No 2 808 533
- Patent for invention No 2 808 534
Specific requirement:
High motivation to work in a scientific environment, sociability, willingness to carry out both experimental and design work with the analysis of the results obtained, basic knowledge in the field of molecular biology, chemistry.
Main publications:
Zhu Y, Zhao R, Feng L, Wang C, Dong S, Zyuzin MV, Timin A, Hu N, Liu B, Yang P. Dual Nanozyme-Driven PtSn Bimetallic Nanoclusters for Metal-Enhanced Tumor Photothermal and Catalytic Therapy. ACS Nano. 2023 Apr 11; 17(7): 6833−6848. doi: 10.1021/acsnano.3c00423. doi: 10.1021/acsnano.3c00423. (Scopus, WOS, Q1)
Yakubova A, Mitusova K, Darwish A, Rogova A, Ageev E, Brodskaia A, Muslimov A, Zyuzin M, Timin A. Calcium carbonate nanoparticles tumor delivery for combined chemo- photodynamic therapy: Comparison of local and systemic administration. J Control Release. 2023 Jul; 359:400−414. doi: 10.1016/j.jconrel.2023.06.012. (Scopus, WOS, Q1)
Koriakina I, Bachinin S, Gerasimova E, Timofeeva M, Shipilovskikh S, Bukatin A, Sakhatskii A, Timin A, Milichko V, Zyuzin Ml. Microfluidic Synthesis of Metal-Organic Framework Crystals with Surface Defects for Enhanced Molecular Loading. Chemical Engineering Journal. 2022 Sep 29; 452. 139 450. doi: 10.1016/j.cej.2022.139 450. (Scopus, WOS, Q1)
Timin A, Postovalova A, Karpov T, Antuganov D, Bukreeva A, Akhmetova D, Rogova A, Muslimov A, Rodimova S, Kuznetsova D, Zyuzin M. Calcium carbonate carriers for combined chemo- and radionuclide therapy of metastatic lung cancer. J Control Release. 2022 Apr; 344:1−11. doi: 10.1016/j.jconrel.2022.02.021. (Scopus, WOS, Q1)
Karpov T, Postovalova, A, Akhmetova D, Muslimov A, Eletskaya E, Zyuzin M, Timin A. Universal Chelator-Free Radiolabeling of Organic and Inorganic-Based Nanocarriers with Diagnostic and Therapeutic Isotopes for Internal Radiotherapy. Chemistry of Materials. 2022 Jul; 34. doi: 10.1021/acs.chemmater.2c01507. (Scopus, WOS, Q1)