English proficiency:
Research projects:
1. Design and synthesis of novel biocompatible nanostructured metal-organic frameworks containing ROS-producing agents for combination radionuclide therapy of malignant tumors.
2. Artificial intelligence technologies for retrosynthetic analysis of large data sets (Big Data) of structure-biological activity relationships.
3. Synthesis of novel PARP inhibitors effective in the treatment of malignant tumors.Research topics:
1. Development of methods for controlling the morphology and biological properties of metal-organic frameworks using ultrasound and microwave irradiation.
2. Development of biocompatible films impregnated with metal-organic frameworks (MOFs) with a broad spectrum of antimicrobial activity.
3. Development and synthesis of structurally variable nanocarriers to enhance localized cancer chemotherapy.
4. A new approach to automated radioactive labeling of micro- and nanoscale metal-organic frameworks for cancer radiation therapy.
5. Oral delivery of a PARP inhibitor using nanocarriers for improved cancer therapy.
6. Polymer-modified hybrid nanocarriers to enhance the efficacy of cancer therapy.
7. Combined chemotherapy and radionuclide therapy using drug carriers for the treatment of tumors of various origins.
8. Transition metal-based MOFs for photocatalytic generation of reactive oxygen species.
9. Development of methods for the synthesis of new biologically active substances effective in the treatment of malignant neoplasms.Field of study:
Research interests:
Research interests focus on the development of modern nanoplatforms, particularly those based on metal-organic frameworks, for targeted drug delivery in oncology. Particular attention is paid to combined systems combining organic and inorganic carriers, which enable the efficient delivery of therapeutic agents directly to tumor tissue while minimizing side effects on healthy cells.
An important area of research is improving the characteristics of nanocarriers (size, surface charge, porosity) and their functionalization to enhance therapeutic efficacy, as well as the development of new biologically active heterocyclic systems for effective chemotherapy and combination therapy.Research highlights:
1. Patent for invention No. 2 836 297.
2. Patent for invention No. 2 815 045.
3. Patent for invention No. 2 829 943.
4. Patent for invention No. 2 808 534.
5. Patent for invention No. 2 829 966.
6. Patent for invention No. 2 831 129.
7. Patent for invention No. 2 810 252.
8. Patent for invention No. 2 770 598.
9. Patent for invention No. 2 818 267.
10. Patent for invention No. 2 722 176.Specific requirement:
High motivation to work in a scientific environment, communication skills, readiness to conduct both experimental and project work with analysis of the results obtained, basic knowledge in the field of molecular biology and chemistry.
Main publications:
A.S. Timin, V.A. Rusakova, K.E. Ilina, A. Rogova, Y.A. Tishchenko, D.R. Akhmetova, I.A. Gorbunova, D.A. Shipilovskikh, D.V. Lipin, S.A. Shipilovskikh, Lecithin-modified hybrid nanocarriers for enhanced locoregional therapy of melanoma: Influence of surface modification on therapeutic response, Journal of Controlled Release, (2025), DOI: 10.1016/j.jconrel.2025.114 020, (IF 12.4), (Q1).
D.R. Akhmetova, Y.A. Tishchenko, A.S. Postovalova, V.A. Rusakova, D.S. Sysoev, M.A. Nadporojskii, A.S. Timin, S.A. Shipilovskikh, Novel Approach of an Automated Radiolabeling of Micro-and Nanoscale UiO-66 MOFs for Internal Radiotherapy of Breast Cancer, ACS Applied Materials & Interfaces, (2026), DOI: 10.1021/acsami.5c19990, (IF 7.8), (Q1).
A.S. Postovalova, V.A. Rusakova, D.R. Akhmetova, Y.A. Tishchenko, D.S. Sysoev, M.A. Nadporojskii, K.S. Sivak, S.A. Shipilovskikh, A.S. Timin, Development of 223Ra-labeled Polymeric Nanocarriers with Variable Administration Routes for Alpha-Therapy of Colorectal Cancer, Drug Delivery and Translational Research, (2026), DOI: 10.1007/s13346−025−1 900−1, (IF 6.9), (Q1).
A. Rogova, Y.A. Tishchenko, R.R. Sergeeva, T.E. Karpov, I.A. Gorbunova, S.V. Faizullina, D.S. Novikova, S.A. Shipilovskikh, A.S. Timin, Oral Delivery of PARP Inhibitor via Gelatin- and Chitosan-Based Nanocarriers for Refined Therapy of Primary and Metastatic Melanomas, International Journal of Biological Macromolecules, (2025), DOI: 10.1016/j.ijbiomac.2025.148 372, (IF 8.7), (Q1).
I.A. Gorbunova, A. Rogova, D.R. Akhmetova, R.Y. Sidorov, E.E. Priakhin, R.R. Makhmudov, D.A. Shipilovskikh, O.S. Epifanovskaya, A.S. Timin, S.A. Shipilovskikh, Design and One-Pot Synthesis of New Substituted Pyrrolo[1,2-a]Thieno[3,2-e]Pyrimidine as Potential Antitumor Agents: In Vitro and In Vivo Studies, Bioorganic Chemistry, (2024), DOI: 10.1016/j.bioorg.2024.107 468, (IF 5.1), (Q1).
T.E. Karpov, A. Rogova, D.R. Akhmetova, Y.A. Tishchenko, A.V. Chinakova, D.V. Lipin, N.V. Gavrilova, I.A. Gorbunova, S.A. Shipilovskikh, A.S. Timin, Encapsulation of a Small-Molecule Drug Based on Substituted 2-Aminothiophenes in Calcium Carbonate Carriers for Therapy of Melanoma, Biomaterials Science, (2024), DOI: 10.1039/D4BM00390J, (IF 6.1), (Q1)
T. Karpov, A. Rogova, K. Ilyina, R. Sergeeva, V. Shienkova, M. Tanabaeva, I. Iskortseva, D. Matveev, A. Brodskaia, A. Skvortsov, S.A. Shipilovskikh, A.S. Timin, Hierarchically Structured CaCO3-Gelatin Carriers for Oral Gastro-Protective Delivery of Broccoli Seed-Derived Isothiocyanates in Combined Chemotherapy of Colorectal Cancer, ACS Applied Materials & Interfaces, (2026), DOI: 10.1021/acsami.6c07955, (IF 7.8), (Q1).
M. Timofeeva, D.S. Dmitriev, D.D. Maltsev, A.A. Lobinsky, V.V. Ivashchenko, S.A. Povarov, D.V. Dogadina, A.S. Timin, V.A. Milichko, V.I. Popkov, S.A. Shipilovskikh, Efficient Solvothermal Synthesis of Defect-Rich Cu-BTC MOF with Enhanced Electrocatalytic Activity in Alkaline Hydrogen Evolution Reaction, Transactions of Tianjin University, (2025), DOI: 10.1007/s12209−024−418-w, (IF 7.8), (Q1).
S.M. Tikhanova, Yu.A. Tishchenko, E.Yu. Stovpiaga, M. Timofeeva, D.V. Lipin, S.A. Povarov, V.A. Milichko, A.S. Timin, S.A. Shipilovskikh, V.I. Popkov, Transition metal-based MOFs for Fenton-like photocatalytic degradation of organic pollutants: Performance, stability, and biocompatibility, Environmental Chemistry and Ecotoxicology, (2025), DOI: 10.1016/j.enceco.2025.01.003, (IF 12.3), (Q1).
A. Rogova, I.A. Gorbunova, T.E. Karpov, R.Yu. Sidorov, A.E. Rubtsov, D.A. Shipilovskikh, A.R. Muslimov, M.V. Zyuzin, A.S. Timin, S.A. Shipilovskikh, Synthesis of thieno[3,2-e]pyrrolo[1,2-a]pyrimidine derivatives and their precursors containing 2-aminothiophenes fragments as anticancer agents for therapy of pulmonary metastatic melanoma, European Journal of Medicinal Chemistry, (2023), DOI: 10.1016/j.ejmech.2023.115 325, (IF 6.7), (Q1).Olympiad Profiles:
- Biology & Biotechnology